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ExcelApplication xla = new ExcelApplication();
Workbook wb = xla.Create();
xla.Save(wb, @"C:\Sales2003\June.xlsxlsx");

ExcelApplication xla = new ExcelApplication();
Workbook wb = xla.Create(ExcelApplication.FileFormat.Xlsx);
xla.Save(wb, Page.Response, "workbook.xlsxlsx", false);

ExcelApplication xla = new ExcelApplication();
Workbook wb = xla.Create(ExcelApplication.FileFormat.Xlsx);
FileStream fstream = new FileStream(@"C:\temp\outfile.xlsxlsx",
FileMode.Create);
xla.Save(wb, fstream);

ExcelApplication xla = new ExcelApplication();
Workbook wb = xla.Create(ExcelApplication.FileFormat.Xlsx);
ExcelTemplate xlt = new ExcelTemplate();
xlt.Open(xla, wb);