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          ExcelApplication xla = new ExcelApplication();
          Workbook wb = xla.Open(@"C:\MySpreadsheet.xlsx");
          Worksheet ws = wb.Worksheets[0];
          ws.SheetProtection.AllowSelectUnlockedCells = true;
          ws.Protect("password");
        

          Dim xla As New ExcelApplication()
          Dim wb As Workbook = xla.Open("C:\MySpreadsheet.xlsx")
          Dim ws As Worksheet = wb.Worksheets(0)
          ws.SheetProtection.AllowSelectUnlockedCells = true
          ws.Protect("password");