Returns whether or not the color is a custom color.

public boolean IsCustomColor{ get; }
Public ReadOnly Property IsCustomColor() As Boolean

For .xls files a custom color is a color that is not part of Excel's default color palette. For .xlsx files, a custom color is any color that has not been retrieved from the legacy palette (through Palette.SetColorAt or Palette.GetColorAt), and is not a system color.

bool customColor = clr.IsCustomColor;
Dim customColor As Boolean = clr.IsCustomColor