Whenever you change the Cell.Style property, that Cell gets its own Style object. However, if you create a new Style object and then call SetStyle or ApplyStyle on the area (Area.ApplyStyle(Style), Area.SetStyle(Style)) or range (Range.ApplyStyle(Style), Range.SetStyle(Style)) you want to affect, ExcelApplication will not have to create a separate Style object for each cell, reducing the amount of memory that is needed.

If you are applying the same style to more than one or two cells, you should say:

//Create a global style
GlobalStyle style = wb.CreateStyle();

//Set a cell's style to the new global style
ws.Cells[0,0].Style = style;

//Set an area's style to the new global style
ws.CreateArea(1,1,5,5).SetStyle(style);

//Set a range's style to the new global style
ws.CreateRange("D5:E6").SetStyle(style);
'Create a global style
Dim style As GlobalStyle = wb.CreateStyle()

'Set a cell's style to the new global style
ws.Cells(0, 0).Style = style

'Set an area's style to the new global style
ws.CreateArea(1, 1, 5, 5).SetStyle(style)

'Set a range's style to the new global style
ws.CreateRange("D5:E6").SetStyle(style)

If you want to apply a single style to all the cells in a column, you can get the ColumnProperties object for that column and call the SetStyle method:

//Get the properties for the column you want to alter
ColumnProperties properties = ws.GetColumnProperties(0);

//Apply a style to that column
properties.ApplyStyle(style);
'Get the properties for the column you want to alter
Dim properties As ColumnProperties = ws.GetColumnProperties(0)

'Apply a style to that column
properties.ApplyStyle(style)

Using one of these two techniques to apply styles will use less memory than creating a new style for each cell or modifying the Cell.Style property directly.

For more information about using Styles in ExcelWriter, please refer to our tutorial Styles in ExcelWriter.